Protamine sulfate enhances lipid-mediated gene transfer
نویسندگان
چکیده
منابع مشابه
Protamine neutralizes chondroitin sulfate proteoglycan-mediated inhibition of oligodendrocyte differentiation
Chondroitin sulfate proteoglycans (CSPGs), which are enriched in demyelinating plaques in neurodegenerative diseases, such as multiple sclerosis (MS), impair remyelination by inhibiting the migration and differentiation of oligodendrocyte precursor cells (OPCs) in the central nervous system (CNS). We herein show that protamine (PRM, also known as a heparin antagonist) effectively neutralizes th...
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ژورنال
عنوان ژورنال: Gene Therapy
سال: 1997
ISSN: 0969-7128,1476-5462
DOI: 10.1038/sj.gt.3300484